Microsoft Word - 304591R3_PAP_10_06_14

1Department of Cellular and Molecular Medicine, Lerner Research Institute, The Cleveland Clinic, Ohio, USA; 2Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Ohio, USA; 3Instituto de Quimica Medica, Consejo Superior De Investigaciones Cientificas (IQM-CSIC), Madrid, Spain; 4Department of Biological Sciences, Case Western Reserve University, Ohio, USA; 5Department of Neurology, Columbia University Medical Center, New York, USA, and; 6Department of Medicine, Medical College of Wisconsin and Blood Research Institute, Blood Center of Wisconsin, Wisconsin, USA.